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Home Medication antifungal

voriconazol

J - Antiinfectives For Systemic Use -> J02 - Antimycotics For Systemic Use -> J02A - Antimycotics For Systemic Use -> J02AC - Triazole Derivatives -> J02AC03 - Voriconazole
Administration category: Free Medicine group: antifungal Brand name: Vfend

Standard dosages

≥ 18 years
Weight ROA Load Dosage
ROA:
 po 		Load:
 400mg 		Dosage:
 200mg 2 dd
ROA:
 iv 		Load:
 6mg/kg 		Dosage:
 4mg/kg 2 dd
Comments:

per os: dag 1 oplaaddosis 400 mg 2 dd, intraveneus: dag 1 oplaaddosis: 6 mg/kg 2 dd

Kidney function

≥ 18 years
ROA GFR Dosage Interval Comments
ROA: iv
GFR:
 10 - 50 		Dosage:
 do not prescribe 		Comments:
 oraal mag wel
GFR:
 <10 		Dosage:
 do not prescribe 		Comments:
 oraal mag wel
Renal elimination: 2%
Dosage: independent on kidney function

Renal function-replacement therapy

CAPD: Aanpassen van de dosis of het doseerinterval is niet nodig. Voriconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof sulfobutyletherbetacyclodextrine (SBECD). Het is onbekend of SBECD wordt verwijderd door peritoneaal dialyse

Hemo dialysis: Aanpassen van de dosis of het doseerinterval is niet nodig. Voriconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof sulfobutyletherbetacyclodextrine (SBECD). SBECD wordt verwijderd door hemodialyse

Interactions

Interaction with (ATC): Expected effect:
Interaction with (ATC):
 L04AD01 - Ciclosporin 		Expected effect:
 verhoging spiegels ciclosporine
Interaction with (ATC):
 L04AD02 - Tacrolimus 		Expected effect:
 verhoging spiegels tacrolimus
Interaction with (ATC):
 L04AA10 - Sirolimus 		Expected effect:
 verhoging spiegels sirolimus
Interaction with (ATC):
 A03FA02 - Cisapride 		Expected effect:
 toename cardiotoxiciteit
Interaction with (ATC):
 R06AX12 - Terfenadine 		Expected effect:
 toename cardiotoxiciteit
Interaction with (ATC):
 B01AA - Vitamin K Antagonists 		Expected effect:
 toename werking orale anticoagulantia
Interaction with (ATC):
 A10B - Oral Blood Glucose Lowering Drugs 		Expected effect:
 versterking effect antidiabetica
Interaction with (ATC):
 N03AB02 - Phenytoin 		Expected effect:
 verlaging plasmaconcentratie voriconazol en verhoging plasmaconcentratie fenytoine
Interaction with (ATC):
 N03AF01 - Carbamazepine 		Expected effect:
 verlaging plasmaconcentratie voriconazol
Interaction with (ATC):
 N03AA02 - Phenobarbital 		Expected effect:
 verlaging plasmaconcentratie voriconazol
Interaction with (ATC):
 J04AB02 - Rifampicin 		Expected effect:
 verlaging plasmaconcentratie voriconazol
Interaction with (ATC):
 J04AB04 - Rifabutin 		Expected effect:
 verlaging plasmaconcentratie voriconazol en verhoging plasmaconcentratie fenytoine en rifabutin

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
Metadata

Swab vid: M-2160.2
Updated: 01/13/2020 - 15:42
Status: Published

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